A series of 2-[(substitutedbenzylidene)amino]-N-(furan-2-ylmethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (IV a-j) were synthesized from 2-amino-N-(furan-2-ylmethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (III). The starting material 2-amino-N-(furan-2-ylmethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (III) was synthesized as per Gewald’s method which was reacted with ten different substituted benzaldehydes to give respective Schiff bases (IV a-j). The newly synthesized compounds were characterized by Melting point, TLC, IR, NMR and Mass spectra. The synthesized compounds were subjected to antibacterial and anti fungal screening involving Gram positive, Gram negative bacterial and fungal species using Streptomycin and Fluconazole as standard at the same concentration. In conclusion, the compound IV (g) 2-[(4-hydroxy-3-methoxybenzylidene) amino]-N-(furan-2-ylmethyl)-tetrahydrobenzo[b]thiophene-3-carboxamide was found.
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